For instructions on how to add an entirely new assignment (eg. in order to combine topics into a single class), see this article.
1. After logging in, navigate to the "Classes" tab and click "View assignments" on the class you wish to add/remove lessons from.

2. Click "View lessons" for the desired assignment.

3. Click "Add/remove lessons"

5. Expand the drop downs for the course/sections to view all of the available content.

6. To add a lesson, check the box next to lesson. To remove a lesson, uncheck the box next to the lesson.

7. Click the "X" in the top-right corner of the window to save changes.
